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New Study Shows Sugar Substitutes
Do Not Overstimulate the Sweet Taste Buds

-- Penn State Scientists Study Sucralose and Other Low Calorie Sweeteners --

(November 18, 2014, Ft. Washington, PA) – A new study from scientists at Penn State University shows that low calorie sweeteners, when used in amounts typical for preparing foods and beverages, do not overstimulate a person's sweet taste buds. These results provide additional evidence that low calorie sweeteners do not lead to sweet cravings and can be a helpful part of a healthy lifestyle. Among the sweeteners used in the study was sucralose, the no calorie sweetening ingredient in SPLENDA® Sweetener Products.

The study, supported by the National Institutes for Health, evaluated the perceived sweetness intensity of various low calorie sweeteners and other sugar substitutes when compared to sugar1. Sugar substitutes are often described as "high intensity" sweeteners and sweeter than sugar, according to the researchers, and misperceptions have grown that people who use them regularly may crave more sweets, causing them to overeat and gain weight.

Researchers recruited 401 people between the ages 18-64 for a series of taste tests conducted over four days. Participants drank between 12 and 15 separate samples containing maple syrup, agave nectar and sugar, as well as various concentrations of the sugar substitutes sucralose, aspartame, acesulfameK, and rebaudiosode A (a compound found in stevia). The drinks were expected to be equivalent in sweetness based on the sweetness potency of each sweetener. The study participants were asked to rate the perceived sweetness of each sample on a scale from 0 to 100, with 100 being the sweetest sensation they could imagine.

The results, published in the International Journal of Obesity, showed that participants perceived the sweetness of sugar substitutes at lower concentrations than real sugar, but the intensity of these sensations was not sweeter than sugar. They indicated that the full calorie sweeteners all had higher sweetness ratings than the sugar substitutes.

Researchers said these results do not support the claim that sugar substitutes produce a harmful effect on people by over stimulating sweet taste receptors to produce hyper-intense sweet sensations. The authors report that they do not evoke sweet sensations that are more intense than sugar.

"This research is helpful in addressing the concern that no or low calorie sweeteners lead to weight gain because they overstimulate a person's sweet taste buds, which has been suggested could cause sweet cravings and/or overeating sweets," says Maureen Conway, R.D., Director of Nutritional Affairs, McNeil Nutritionals, LLC. "The data shows just the opposite – that the sweetening ingredients in sugar substitutes like SPLENDA® Sweetener Products do not overstimulate people's taste buds. This data builds on previous science that shows that SPLENDA® No Calorie Sweetener, as part of a healthy meal plan and with regular physical activity, can be an excellent way to help with weight loss and weight maintenance."

SPLENDA® Brand Sweetener has been used safely by millions of people around the world for more than 20 years, supported by research data from more than 100 studies. Both the American Diabetes Association (ADA) and the Academy of Nutrition and Dietetics (AND) support the use of low calorie sweeteners such as sucralose as a useful tool in managing weight and diabetes. For more information, visit www.splenda.com and www.splendaliving.com.

END

1Antenucci RG, Hayes JE. Nonnutritive sweeteners are not supernormal stimuli. Int J Obes, 2014; doi: 10.1038/ijo.2014.109.

Links to third-party websites are provided solely for convenience. McNeil Nutritionals, LLC is not responsible for the content of such websites, and users are solely responsible for compliance with any terms of use thereon.

 

 

New Study on Successful Weight Loss Reports
Low Cal or Sugar Free Drinks Help People with Weight Management

-- National Weight Control Registry Investigates Behaviors for Success --

(September 16, 2014, Ft. Washington, PA) - A new study of people who have lost substantial weight and kept it off long term finds that low calorie or sugar free beverages were a helpful tool in their weight management efforts, as reported by the study participants.

The study was conducted by the National Weight Control Registry (NWCR), which is the largest longitudinal study of people who have lost significant amounts of weight and kept it off for long periods of time. The NWCR was established in 1993 and tracks over 10,000 individuals who have lost at least 30 pounds and kept off the weight for more than one year. Detailed questionnaires and annual follow-up surveys are used to examine the behavioral and psychological characteristics of weight maintainers, as well as the strategies they use to maintain their weight losses.

This latest research from NWCR, in adults who sustained a large weight loss, found that most of these individuals included low or sugar-free beverages in their diet1. And 78% of these individuals reported that using low or sugar free drinks helped them control or reduce total food or calorie intake. A substantial number of these participants also reported that making changes in their patterns of beverage consumption were "very important" in their efforts to lose weight (42%) or maintain weight loss (40%).

This study was published in Obesity, the journal of The Obesity Society, and evaluated the responses of 434 NWCR members during the period of November 2012 through March 2013. The researchers describe the study as the "first to our knowledge to explore motivations and strategies behind the consumption of low/no calorie sweetened beverages in successful weight loss maintainers." Participants in the study had sustained their significant weight loss for an average of greater than seven years.

"The results show that 10% of the study subjects drank sugar-sweetened beverages on a regular basis," says Maureen Conway, R.D., Director of Nutritional Affairs, McNeil Nutritionals, LLC. "Notably, of this group, less than 1% reported drinking full-calorie (sugar-sweetened) soda. In contrast, 53% of the people drank low or no calorie (diet or sugar free) beverages on a regular basis, which strengthens the evidence that diet sodas don't cause weight gain. The researchers conclude that regular use of low or no calorie sweetened beverages is common in people who have maintained their weight loss."

According to the study findings, the top four reasons people used low calorie or sugar free beverages were reported as:

  • Taste (54%)
  • To satisfy thirst (40%)
  • As part of a routine (27%)
  • To reduce calories (22%)

Regardless of their primary reason for using low or sugar free drinks, 78% of participants reported using them to help control or reduce the total amount of food or calories they consumed.

"There have been conflicting studies published in recent years on the effect of low calorie sweeteners in weight management," Ms. Conway says. "Results from this new study provide important insights about people who have accomplished their weight loss goals and the strategies that worked for them. Low calories sweeteners like SPLENDA® No Calorie Sweetener can be an easy way to help reduce the daily intake of calories and carbohydrate from added sugars. It's one of many small changes people can make in their daily routines that can add up to meaningful changes in their weight management efforts over time."

SPLENDA® Brand Sweetener has been used safely by millions of people around the world for more than 20 years, supported by research data from more than 100 studies. Both the American Diabetes Association (ADA) and the Academy of Nutrition and Dietetics (AND) support the use of low calorie sweeteners such as sucralose as a useful tool in managing weight and diabetes. For more information, visit www.splenda.com and www.splendaliving.com

END

1Victoria A. Catenacci, Zhaoxing Pan, et al: Low/No Calorie Sweetened Beverage Consumption in National Weight Control Registry. Obesity. Full article available at Wiley Online Library; http://onlinelibrary.wiley.com/doi/10.1002/oby.20834/full

Links to third-party websites are provided solely for convenience. McNeil Nutritionals, LLC is not responsible for the content of such websites, and users are solely responsible for compliance with any terms of use thereon.

 

 

Study Looks at Desserts with Sucralose and Dextrin
As Part of Healthy Diet for Type 2 Diabetes

- Research Aims to Assist With Dessert Choices for Type 2 Diabetic Patients -

- Can Help People Meet Dietary Guidelines for Reducing Added Sugar -

(July 15, 2014, Ft. Washington, PA) -- Enjoying desserts as part of a healthy diet can be a challenge for people with diabetes and summertime is no exception.  Strawberry shortcake, fruit tarts and chocolate treats are among seasonal favorites found at many summer parties. Recent research offers encouraging news that some desserts made with added fiber and sucralose, the no calorie sweetening ingredient in SPLENDA® Sweetener Products -- in place of added sugar -- may help with maintaining blood sugar and insulin levels in people with type 2 diabetes.

The research was published in the Review of Diabetes Research and conducted at the Diabetes Center of the General Hospital of Nikaea in Athens, Greece (http://bit.ly/1oRIAAB). Researchers proposed that some desserts producing a low sugar response may be appropriate for people with type 2 diabetes and can help them adhere to dietary guidelines for reducing added sugar.  

Researchers compared blood sugar, insulin and c-peptide responses (which gauge how much insulin the body is producing) in people with type 2 diabetes after eating desserts made with sucralose and dextrin (a common soluble fiber), to the same responses in those people after eating the desserts made with sugar.

"Medical experts agree that one key to living well with diabetes is keeping blood sugar levels in the recommended range throughout the day," says Maureen Conway, R.D., Director, Nutritional Affairs, McNeil Nutritionals, LLC. "For people with diabetes, sweets are more than just extra calories, they can also impact their blood sugar. The study was designed to provide data that would assist with the dessert choices for people with type 2 diabetes. The results offer helpful insights into healthy choices and meal planning."

As part of the study, 70 people with type 2 diabetes were divided into seven groups of ten. On three occasions after an overnight fast, each participant received either a meal (bread and cheese); or a meal and dessert made with sucralose and dextrin; or a meal and dessert made with sugar. Differences in glucose, insulin, and C-peptide were evaluated at five different points in time after each meal. Among the desserts used in the study were cake, pastry cream, strawberry jelly, chocolate, and napoleons.

The results showed that the participants who ate cake, strawberry jelly or pastry cream made with sucralose and dextrin had lower after-meal glucose and insulin levels than after eating the same desserts made with sugar. Similar effects on glucose, insulin, and C-peptide levels at specific time points were reported for the milk dessert, napoleon and chocolate made with sucralose. Crème caramel showed no effect. The researchers concluded that the desserts in the study made with sucralose and soluble fiber did not raise after-meal levels of glucose, insulin or C peptide in comparison with meal consumption. In addition, the study largely showed a lower blood glucose and insulin response for meals with desserts made with sucralose and soluble fiber.

"The study supports the wide body of research that confirms sucralose does not increase blood sugar or insulin levels," Conway says. "SPLENDA® No Calorie Sweetener Products can be a great tool in diabetes meal-planning – allowing people with diabetes to enjoy some desserts and still keep their blood sugar levels in check. Desserts vary in their calorie and carbohydrate content, but with careful planning some lower sugar options can be part of a healthy meal plan. The researchers also noted that their study was short term and that further research can add additional insights into diabetes meal planning."

Sucralose, the no calorie ingredient in SPLENDA® Sweetener Products, is not sugar and the body does not recognize it as such. Unlike sugar, sucralose is not broken down for energy. It is not a source of carbohydrate or glucose, and clinical studies have shown it has no effect on blood glucose levels, insulin secretion or blood levels, glycosylated hemoglobin levels (HbA1c), or blood glucose control.

A separate study from Wu et al., published last year in Diabetes Care, a journal of the American Diabetes Association (http://bit.ly/1hjre0B), showed that consuming sucralose in a drink is shown to have the same effect as water on a person’s sugar and insulin levels.

"Both these studies provide strong evidence that SPLENDA® Brand Sweetener can be used safely by everyone, including pregnant women, children and people with diabetes," Conway says. "And using SPLENDA® No Calorie Sweetener, as part of a healthy meal plan with regular physical activity, can be an excellent way to help with weight loss and weight maintenance."

SPLENDA® Brand Sweetener has been used safely by millions of people around the world for more than 20 years, supported by research data from more than 100 studies. Both the American Diabetes Association (ADA) and the Academy of Nutrition and Dietetics (AND) support the use of low calorie sweeteners such as sucralose as a useful tool in managing weight and diabetes. For more information, visit www.splenda.com and www.splendaliving.com

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NEW REVIEW OF STUDIES ON LOW CALORIE SWEETENERS
FINDS POSITIVE IMPACT ON WEIGHT LOSS, WAIST SIZE AND BODY FAT

-- Presentation at Experimental Biology 2014 Highlights Abstract –

 

(Ft. Washington, PA, May 13, 2014) – The role of low calorie sweeteners (LCS) in weight management and appetite has been a topic of growing public interest in recent years. Now, a new analysis of research spanning 35 years finds that replacing sugar with low calorie sweeteners helps people lose weight, reduce waist size and decrease body fat. Importantly, the analysis also shows that low calorie sweeteners do not cause weight gain.

"As overweight and obesity-related health conditions include cardiovascular disease, type 2 diabetes and some types of cancer, it's critical to identify strategies that help facilitate weight loss or weight maintenance," says Vanessa Perez, Ph.D., who presented the study abstract at the annual meeting of Experimental Biology, a multidisciplinary scientific meeting.1,2 "Based on the gold standard study design in medical research - the randomized controlled trial - the results show that using low calorie sweeteners resulted in statistically significant reductions in body weight, BMI, fat mass, and waist circumference."

Dr. Perez and her colleague, Paige E. Miller, Ph.D., M.P.H., conducted a meta-analysis of published studies dating back to 1976. Meta-analysis, a statistical technique that quantitatively combines the findings from multiple, independent studies, was used to assess the effectiveness of low-calorie sweeteners. The benefits of meta-analysis include a consolidated and quantitative review of the large, often complex, and sometimes conflicting body of research.

"Conflicting research on low calorie sweeteners and body weight have led to some debate about the relationship between low calorie sweeteners and body weight," says Dr. Perez, a Managing Scientist at the Center for Epidemiology and Computational Biology, Exponent, Inc. "Using meta-analysis techniques, we evaluated 15 randomized controlled trials and nine prospective observational cohort studies to examine the relationship between low calorie sweeteners and body weight and composition.

"Data from the randomized controlled trials indicate that substituting low calorie sweeteners in place of sugar does not cause weight gain and may be a useful tool in helping people comply with their weight loss and weight management plans," Dr. Perez explains. "The results also show that use of these sweeteners resulted in a modest, but statistically significant, reduction in all outcomes examined, including body weight, fat mass and waist circumference. Additionally, the results do not support recent hypotheses that low calorie sweeteners increase appetite and sweet cravings."

Dr. Perez and her colleague also evaluated results from prospective observational cohort studies, which showed inconsistent results. The authors note that these studies are limited and difficult to interpret because few observational studies adequately account for potential factors that could impact the outcome, such as a person's diet and other lifestyle practices.

Dr. Perez noted that, while past reviews of low calorie sweeteners and weight control have been published, the present meta-analysis is the most comprehensive scientific evaluation to date of low calorie sweeteners and body weight and composition. The complete study has been accepted for publication later this year in the American Journal of Clinical Nutrition (AJCN). The research was funded by the North American Branch of the International Life Sciences Institute (ILSI )3.

Both the American Diabetes Association (ADA) and the Academy of Nutrition and Dietetics (AND) support the use of low calorie sweeteners such as sucralose as a useful tool in managing weight and diabetes. SPLENDA® No Calorie Sweetener Products (sucralose) have been used safely by millions of people around the world for more than 20 years, supported by research data from more than 110 studies.

"Leading nutrition and health experts recommend a balanced approach to weight loss and weight management, including healthy eating plans, portion control and increasing physical activity ," says Lee Grotz, Ph. D. , Director of Medical Affairs, McNeil Nutritionals, LLC. "SPLENDA® No Calorie Sweetener can be an easy way to help reduce the daily intake of calories and carbohydrate from added sugars – without sacrificing taste. It's one of many small changes people can make in their daily routines that can add up to meaningful changes in their weight management efforts over time."

For more information about SPLENDA, visit www.splenda.com or www.foodinsight.org.

END

1 Experimental Biology is a multidisciplinary scientific meeting sponsored by six societies from professionals in the fields of anatomy, physiology, biochemistry and pathology, nutrition and pharmacology. The 2014 meeting was held April 26-30 in San Diego, CA

2http://bit.ly/1suHVYc
Miller, PE, Perez, V., (2014) Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohorts. FASEB J., 28, 391.1.

3 All opinions, findings, and conclusions made herein are those of the authors and do not necessarily reflect the views of ILSI North America or any other organization or agency

 

 

STUDY FINDS SUCRALOSE, SWEETENING INGREDIENT IN
SPLENDA® SWEETENER PRODUCTS, HAS SAME EFFECT AS WATER ON THE BODY

 

-- Results Add to Evidence that SPLENDA® is Safe for People with Diabetes –

 

(Ft. Washington, PA, March 18, 2014) -- Consuming sucralose in a drink is shown to have the same effect as water on a person’s sugar and insulin levels, according to a study reported in Diabetes Care, a journal of the American Diabetes Association1. Sucralose is the no calorie sweetening ingredient in SPLENDA® Sweetener Products.

The study was led by Tongzhi Wu, MD, PhD, at the University of Adelaide School of Medicine, and funded by the National Health and Medical Research Council in Australia. The results showed that neither sucralose alone, or when combined with another no calorie sweetener, acesulfame potassium (AceK), had any effect on insulin secretion or blood sugar.

In the study, Wu and his team followed ten healthy men who drank four different drinks on four different occasions after an overnight fast. The four drinks were water; water with sucralose; water with AceK; and water with both sucralose and AceK. Ten minutes later each one drank a sugar solution.

The participant’s sugar, insulin, and GLP-1 blood levels were measured before, and for four hours after, drinking the sugar solution. (GLP-1 is a hormone known to slow gastric emptying and has a role in appetite regulation.) The results showed no differences in outcomes for any of these measures, whether the men drank plain water, or water sweetened with either or both sweeteners. It should be noted that using all men in such a study is a way to minimize the possibility of effects unrelated to testing. For example, hormonal changes that can occur with menstruation can influence insulin levels2,3 .

“Our findings are … consistent with previous reports…” the authors state, and they concluded that “… sucralose and AceK, either alone or in combination, have no acute effect on gastric emptying, GLP-1, or glycemic responses after oral glucose in healthy humans.”

In their comments in Diabetes Care1, Dr. Wu and colleagues point out that a previous study reported that drinking diet soda increased GLP-1 levels. This result was further interpreted to mean that the artificial sweeteners could potentially impact metabolism and increase a person’s sugar levels.

In contrast, Dr. Wu noted that, “The design of that study was, however, suboptimal, as the diet soda contained a number of substances (including caramel color, gum acacia, natural flavors, citric acid, potassium benzoate, phosphoric acid, and potassium citrate) that were not controlled for.” Consequently, Dr. Wu and his team chose to give participant’s in their study sweeteners in water to avoid the potential effect of these other substances on glucose, insulin or GLP-1.

“The Wu study provides more evidence that SPLENDA® can be used safely by everyone, including pregnant women, children and people with diabetes,” says Maureen Conway, R.D., Director of Nutritional Affairs for McNeil Nutritionals, LLC. “This is especially meaningful for people with diabetes and their caregivers. Foods and beverages sweetened with SPLENDA® No Calorie Sweetener can be a great way for people to enjoy the foods they love as part of their diabetes meal plan. And using SPLENDA® with regular physical activity can be an excellent way to help with weight management.”

Sucralose, the no calorie ingredient in SPLENDA® Sweetener Products, is not sugar and the body does not recognize it as such. Unlike sugar, sucralose is not broken down for energy. It is not a source of carbohydrate or glucose, and clinical studies have shown it has no effect on blood glucose levels, insulin secretion or blood levels, glycosylated hemoglobin levels (HbA1c), or blood glucose control.

SPLENDA® Sweetener Products have been used safely by millions of people around the world for more than 20 years, supported by research data from more than 110 studies. Both the American Diabetes Association (ADA) and the Academy of Nutrition and Dietetics (AND) support the use of low calorie sweeteners such as sucralose as a useful tool in managing weight and diabetes. For more information, visit www.splenda.com or www.foodinsight.org.

END

1 Wu T, Bound MJ, Standfield SD, Bellon M, Young RL, Jones KL, Horowitz M, Rayner CK. Artificial sweeteners have no effect on gastric emptying, glucagon-like peptide-1, or glycemia after oral glucose in healthy humans. Diabetes Care, 2013. 36: e202-e203. (Available at: http://care.diabetesjournals.org/content/36/12/e202.full )

2Brennan IM, Feltrin KL, Nair NS, Hausken T, Little TJ, Gentilcore D, Wishart JM, Jones KL, Horowitz M , Feinle-Bisset C.
Effects of the phases of the menstrual cycle on gastric emptying, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women. Am J Physiol Gastrointest Liver Physiol. 2009. 297:G602-610. (Available at: http://www.ncbi.nlm.nih.gov/pubmed/19556358)

3Schisterman EF, Mumford SL, Sjaarda LA. Failure to consider the menstrual cycle phase may cause misinterpretation of clinical and research findings of cardiometabolic biomarkers in premenopausal women. Epidemiol Rev. 2014. 36:71-82. (Available at: http://www.ncbi.nlm.nih.gov/pubmed/24042431)

 

 

McNeil Nutritionals, LLC

Statement on Schiffman Sucralose Overview Paper


 

A recent paper from Schiffman et al. on sucralose, the sweetening ingredient in SPLENDA® Sweetener Products, does a disservice to consumers who use sucralose as a safe and effective tool in managing their weight or diabetes. The paper is a reiteration of assertions Schiffman has made before, based largely on a study from 2008 (Abou-Donia et.al.). An expert panel report1 later found that the Abou-Donia study was deficient in several areas and the conclusions were not consistent with published literature or the data presented.

SPLENDA® has been used safely by millions of people around the world for more than 20 years and consumers can continue to have confidence in their choice of SPLENDA®. Global health authorities have reviewed more than 110 studies on sucralose and agree that it can be used safely by everyone. Both the American Diabetes Association (ADA) and the Academy of Nutrition and Dietetics (AND) support the use of sucralose as a useful tool in managing weight and diabetes. Additionally, in 2012, international experts in food safety, health and nutrition held a conference in Italy to reassess the safety of no and low calorie sweeteners, including sucralose. They endorsed previous regulatory conclusions that all approved low and no calorie sweeteners “are perfectly safe.” 2

1Expert Panel report on a study of Splenda in male rats

2http://eon.businesswire.com/news/eon/20120111005753/en/sweeteners/low-calorie-sweeteners/artificial-sweeteners

 

 

SPLENDA® Brand Sweetener and Weight Management
September 2013

Quite a bit of misinformation has been circulating about low-calorie sweeteners, including questions about their use in weight management. However, the overall data shows that low-calorie sweeteners can be useful in strategies for weight management.

We encourage people to make informed choices about using SPLENDA® Brand Sweetener by reviewing the credible research available on sucralose (the no-calorie sweetening ingredient in all SPLENDA® Sweetener Products) and on low-calorie sweeteners in general.

The breadth of scientific research does not support the theory that low-calorie sweeteners cause people to gain weight or increase their appetite. In fact, studies of persons using low-calorie sweeteners show that low-calorie sweeteners can be useful in weight management strategies.

Additionally, rigorous large lifetime studies of rats that received amounts of sucralose comparable in sweetness to over 40 pounds of sugar per day showed that sucralose does not cause increases in body weight. Overall, there is a significant range of data that supports sucralose and other low-calorie sweeteners as positive tools in sensible weight management strategies.

Professional organizations including the Academy of Nutrition and Dietetics support these conclusions, and the American Diabetes Association (ADA) offers this advice: “As part of a weight loss or weight management plan, artificial sweeteners can provide low-calorie options for desserts and other treats instead of cutting them out completely.”

The theory that low-calorie sweeteners can contribute to weight gain by tricking the body to crave more calories is not supported by overall research. In fact, low-calorie sweeteners have been shown to be useful in weight loss programs.

While newer studies have sent some confusing messages, it is important to know that not all new studies, or the headlines that sometimes accompany them, are designed to actually assess cause and effect. For example, many of the recent articles on low-calorie sweeteners are from observational studies. These are studies that can show certain associations, but cannot test for cause and effect. In contrast, studies designed to test cause and effect show no evidence that low-calorie sweeteners cause weight gain. This is not at all surprising, since intake of these sweeteners provides little or no nutrients that can be stored as energy for weight gain.

Consumers should always take a practical, balanced approach toward weight management. SPLENDA® No Calorie Sweetener is not the single answer to a healthier lifestyle, nor is it a cure for obesity. But it can be an easy way to help reduce the daily intake of calories and carbohydrate from added sugars – without sacrificing taste. It’s one of many small changes people can make in their daily routines that can add up to meaningful changes in their weight management efforts over time.

For more information about the research on low-calorie sweeteners, visit these links:

 

 

McNeil Nutritionals, LLC

Statement on Sucralose and the Center for Science in the Public Interest (CSPI)


 

Recently, the Center for Science in the Public Interest (CSPI) made comments about the safety of sucralose. Their comments were based on pending data from an Italian research lab. That data has not been published and, to our knowledge, has not been peer reviewed, which is a critical step in validating research. Previous studies from this lab have been questioned by international food safety authorities, partly because the researchers did not follow accepted standards for assessing safety.1

In contrast, more than 110 studies conducted over 20 years have proven the safety of sucralose, the sweetening ingredient in SPLENDA® Sweeteners. Worldwide authorities, including the U.S. Food and Drug Administration, the European Food Safety Authority, Health Canada, and the World Health Organization, have reviewed these studies and confirm that results show no link between sucralose and any form of cancer. The National Cancer Institute (NCI) and the American Cancer Society (ACS) are among numerous health organizations that support this conclusion1.

SPLENDA® Sweeteners have been enjoyed safely by millions of people around the world and are an excellent tool for people looking to reduce added sugar in their diet. The American Diabetes Association and the Academy of Nutrition and Dietetics both support that sucralose can be a useful tool in managing weight and diabetes. People can continue to use SPLENDA® safely and we urge anyone with questions about using SPLENDA® Sweeteners to speak with a healthcare professional

1 U.S. Food and Drug Administration, European Food Safety Authority.

2http://www.cancer.gov/cancertopics/factsheet/Risk/artificial-sweeteners

http://www.cancer.org/Healthy/EatHealthyGetActive/ACSGuidelinesonNutritionPhysicalActivityforCancerPrevention/acs-guidelines-on-nutrition-and-physical-activity-for-cancer-prevention-common-questions

http://eon.businesswire.com/news/eon/20120111005753/en/sweeteners/low-calorie-sweeteners/artificial-sweeteners

 

Statement on Washington University/Pepino Study
June 2, 2013

People who use SPLENDA® Brand Sweetener (sucralose) should not be misled by the recent study from Washington University on sucralose and its potential to affect the body's sugar levels. This small study in morbidly obese people does not reflect the extensive body of science that shows sucralose is safe and can be used by everyone, including people with diabetes. SPLENDA® has been available for more than 20 years and has been used by millions of people around the world, and rigorous research has shown that it does not raise people’s sugar or insulin levels. The American Diabetes Association and the Academy of Nutrition and Dietetics both support the role of sucralose as a useful tool in managing weight and diabetes. People can continue to use SPLENDA® safely and we urge anyone with questions about using SPLENDA® to speak with their health care professional. Here is more important information about the study:

 

  • The study was of short duration (two separate test days, one week apart) and involved people who did not have diabetes.
  • The study looked at how the participants responded to a sugar-sweetened drink consumed immediately after drinking water or water containing sucralose. It is normal for blood sugar levels to rise after consuming a sugar-sweetened drink, whether or not sucralose was consumed beforehand.
  • The researchers did not point out that even the highest sugar level observed in the participants is considered to be normal, based on normal ranges set by health care professionals. This means no clinical significance can or should be drawn from the differences observed between the two people who drank unsweetened water, compared to those who drank water with sucralose.
  • Moreover, researchers did not control for conditions that could have affected the participants' response to the sugar test drinks -- such as diet or exercise -- in the days before each of the two testing days. Changes in exercise can particularly affect insulin responses.
  • The study involved people who were morbidly overweight (avg BMI = 41), which could affect the way their bodies respond to consuming sugar. It's common for people with extreme obesity to have a different response to sugar than people of normal weight.
  • Importantly, more than 120 studies over a 20-year period have demonstrated that sucralose is a safe sweetener that can be used by everyone, including children, women who are pregnant or nursing, and people with diabetes. These studies included clinical trials in people with Type 1 and Type 2 diabetes and in people without diabetes, where sucralose was consumed in high doses for months. The total evidence shows that sucralose has no negative effects on blood sugar levels, insulin, or hemoglobin A1c (a measure of long-term blood glucose control).

 

Learn more about how SPLENDA® Brand Sweetener is suitable for people with diabetes.

 

Sucralose and the Environment

Sucralose, the sweetening ingredient in SPLENDA® Sweetener Products, has been rigorously tested to meet U.S. and international regulations necessary for approving a food ingredient for use in the general population. Over 120 studies have been conducted to demonstrate that sucralose can be used safely by all populations, including children, women who are pregnant or nursing, and people with diabetes. Additionally, studies have been done to study the potential for environmental impact and the results showed that sucralose is safe in the environment and does not bioaccumulate in animals or plants.

Specifically, the U.S. Food and Drug Administration (FDA) reviewed numerous studies conducted to investigate the potential for environmental impact, before approving sucralose for marketing in the U.S. In the FDA's initial approval of sucralose as a food additive, the FDA stated:

"The agency has carefully considered the potential environmental effects of this action. FDA had concluded that the action [approval of sucralose] will not have a significant impact on the human environment, and that an environmental impact statement is not required." (Federal Register, Vol. 63, No. 64, Friday, April 3, 1998, Rules and Regulations, page 16431).

Additionally, as part of the regulatory approval process for sucralose, a comprehensive range of scientific studies on sucralose was conducted to investigate the potential impact on plant and aquatic life. The data was submitted to regulatory agencies around the world, including Canada, the European Union, Japan, and Australia. All environmental studies on sucralose were conducted to internationally agreed protocols validated for regulatory purposes. Specific studies clearly demonstrate that sucralose has no adverse effect on fish, invertebrates (e.g., water flea), algae or higher plants. These studies showed no effects at concentrations of sucralose that were many times greater than would be found in the environment. Every regulatory authority who reviewed the environmental data on sucralose arrived at the same conclusion: Sucralose has no adverse effect on the environment.

Regulatory Toxicology and Pharmacology journal publishes new sucralose papers (October 2009)

The scientific journal, Regulatory Toxicology and Pharmacology, has published two articles affirming the safety of sucralose. Sucralose is the sweetening ingredient in SPLENDA® Sweetener Products and is used by millions of people worldwide to reduce their use of sugar as part of a healthier lifestyle. Both papers on sucralose appeared in the October 2009 issue of the journal (Volume 55, Issue 1).

In the paper, "Expert Panel Report on a Study of SPLENDA in Male Rats," internationally recognized experts in nutrition, weight management, toxicology, food safety, medical and public health and other relevant areas, assessed the design, results and conclusions from a small study in male rats given a retail SPLENDA® product. The study was funded by the Sugar Association and the study investigators had raised certain questions about possible adverse effects. The Expert Panel found that the study was deficient in several critical areas, had serious design flaws, and did not represent evidence of any adverse health effects of either sucralose or SPLENDA® No Calorie Sweetener. They noted that the safety data surrounding sucralose has "been rigorously evaluated by experts around the world" and that the available evidence demonstrates that Splenda and sucralose are safe. (For more information, go to: www.sciencedirect.com, Browse by Title, Regulatory Toxicology and Pharmacology, Vol. 55, Issue 1)

A second paper, "An Overview of the Safety of Sucralose," provides a comprehensive review of some 110 studies conducted on sucralose, including a detailed discussion of the fate of sucralose in the body and key findings with regard to sucralose safety. The article also describes the extensive reviews conducted by food safety and public health authorities from around the world, and reports that these "trained safety and health protection authorities have concluded from [the scientific] database [on sucralose], that sucralose is a safe food ingredient that can be safely consumed for a lifetime." The paper also notes that these expert independent evaluations resulted in "no limitations for use by any population subtypes," and, for example, is "safe for use by children and people with diabetes." (For more information, go to: www.sciencedirect.com, Browse by Title, Regulatory Toxicology and Pharmacology, Vol. 55, Issue 1)

"SPLENDA® Brand Sweetener is one of the most vigorously studied food ingredients, and we're pleased that leading exerts in the fields of nutrition and public health continue to verify its excellent safety profile," says Roberto Moran, M.D., Senior Director, Clinical Medical Affairs, McNeil Nutritionals, LLC. "SPLENDA® Sweetener Products are valuable tools for people who want to decrease the amount of calories and carbohydrates from sugar to help them manage their health and wellness."

McNeil Nutritionals, LLC, is a global marketer of innovative nutritional products. The company's mission is to give people the ability to actively manage their own health. McNeil Nutritionals, LLC, markets SPLENDA® Sweetener Products, new SUN CRYSTALS® All-Natural Sweetener with Stevia, VIACTIV® Dietary Supplements, LACTAID® Milk and Dietary Supplements, and BENECOL® Products. McNeil Nutritionals, LLC, is headquartered in Fort Washington, PA.

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